genetic models CLARIFICATIONS NEEDED

KEYWORDS TO BE CLARIFIED



allelic association, genotypic association (PLINK)



genotype relative risk



allele risk



genetic models = diallelic polymorphisms:

dominant

recessive

co-dominant

overdominant

additive (log-additive)

multiplicative



cf PLINK tutorial section Association

cf Moreno et al. SNPstats

cf Lewis 2002: Genetic association studies: design, analysis interpretation.

cf Handbook of Statistical genetics. Eds. Balding, Bishop ...: chapters 36, 37 by Clayton, and Morris/Cardon

cf SNPGWA tutorial - gives exact documentation for calculations. explains CochranArmitage TREND TEST for log-additive genetic/inheritance model. involves NEWTON-RAPHSON algorithm /iterative process/ simply --- complicated



cf summarize - assumptions of HWE for allelic multiplicative, genotypic tests??

-

can log-additive be computed in SPSS

cf coding recommendations by CLAYTON, Morris -- logistic reg model including ADDITIVE and DOMINANCE factor.

- furthermore - cf likelihood ratio tests for model selection, cf Moreno aIC, BIC...



cf MODELS for binary data /disease status/ and for quantitative phenotypes.